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Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC, Brock JE, RichardsonAL, Weinberg RA (2009) A pleiotropically acting microRNA, miR-31, inhibits breast cancermetastasis. Like nitratesit also acts as a NO donor—relaxes blood vesselsby increasing cGMP. Patientshad previously undergone an electrocardiogram (ECG),echocardiography, Holter monitoring, and tilt table test-ing.

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Changes to PIP or VR after an ABG wereconsistent with the protocol 42 % of the time, butthe most common clinical decision was nochange to either PIP or VR (46 %). This is generally accomplished by establishing a rationale forthe study by presenting reasoned arguments supported by the published literature on thetopic of investigation.

Nevertheless, this difference could not be reproduced in vivo. These results are also consistent with radiolabeling studies inanimals. Includes several differentphenotypes with variable age of onset and longevity.

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